CBF and CMRO2 Coupling

• Fly in the ointment

  • Fox and Raichle (1986): CMRO2 during neuronal activation uncoupled from CBF and CMRglu
  • Prichard et al. (1991): lactate increase detected during visual stimulation

TCA

Cycle

Glucose

ATP ADP

Oxidative

30 ATPs per glucose

Non-Oxidative Glycolysis

2 ATPs per glucose

Glucose

oxidative

phosphorylation

Pyruvate

lactate

ATP

Acetyl CoA

CoA

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