CBF and CMRO2 Coupling

• Historical Perspective

  • Roy and Sherrington, 1890: proposed coupling of CBF and metabolism
  • Coupling confirmed in resting brain 1970s–1980s. Almost all neuronal energy derives from oxidative glucose metabolism

?CBF

CBF

?CBF

CBF

?CMRglu

CMRglu

?CMRO2

CMRO2

slope = 1.0

slope = 1.0

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