Coupled or Uncoupled O2 Metabolism?

• assume (i) CBF increases occur by velocity increase, (ii) oxygen extraction is efficient

?CBF

CBF

?CBF

CBF

?CMRO2

CMRO2

OEF

100%

50%

0%

100%

50%

0%

-100%

0%

100%

0%

5%

10%

OEF(CBF) = 1 - (1 - OEF0)CBF0/CBF

Buxton and Frank, JCBFM, 17:64, 1997

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