Chapter 2

Author: Albert Gjedde (Aarhus University Hospital)

Section 2.1. Understanding the Haemodynamic Response to Neuronal Activation
Section 2.2. The Work of the Brain: The Energy Cost of Information Transfer
Section 2.3. The nature of metabolic work for information transfer in the brain
2.3.1: Ion transport
2.3.2: Neuronal excitation

Section 2.4. Biochemical Pathways Providing Energy for Brain Work
2.4.1: Hydrolysis of phosphocreatine
2.4.2: Glycolysis
2.4.3: Oxidative metabolism

Section 2.5. Metabolic compartmentation and Brain Activation
2.5.1: Interaction of neurons and astrocytes in the metabolism of glutamate

Section 2.6. Understanding the Quantitative Relationship Between Work and Energy Metabolism
2.6.1: Average steady-state energy demand
2.6.2: Energy demands of neuronal excitation

Section 2.7. Balancing Energy Production and Utilisation
2.7.1: Hydrolysis of phosphocreatine
2.7.2: Glycolysis
2.7.3: Oxidative phosphorylation

Section 2.8. Local Coupling of Neuronal Activity to the Haemodynamic Response
2.8.1: Relationship between increased oxidative metabolism and increased local blood flow
2.8.2: Physiological regulation of blood flow

Section 2.9. Conclusions