Coupled or Uncoupled O2 Metabolism?

• Limited oxygen diffusion model (Buxton & Frank, 1997)

Capillary Bed

O2

O2

O2

CMRO2 = OEF ? CBF

HbO2

dissociation

curve

Venule

O2

O2

Buxton and Frank, JCBFM, 17:64, 1997

Arteriole

O2

HbO2

Hbr

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