Functional Mapping Methods

28/06/99


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Table of Contents

Basic Physiology of fMRI

Functional Mapping Methods

The Neuron

Brain Metabolism

Physiological Correlates of Brain Electrical Activity

CBF and CMRO2 Coupling

CBF and CMRO2 Coupling

Coupled or Uncoupled O2 Metabolism?

Coupled or Uncoupled O2 Metabolism?

Transient Uncoupling?

Balloon Model (Buxton et al.)

Summary

BOLD fMRI

BOLD fMRI: Preview

Magnetic Properties of Hemoglobin

Magnetic Field Distortions Around a Cylinder

Magnetic Field Distortions Around a Cylinder

Variation with O2 Saturation

Variation with ?

fMRI BOLD: Overview

Limits to Resolution

Fast Response (‘The Early Dip’) (Optical Imaging Results)

BOLD Signal Response

Spin Echo Versus Gradient Echo

Field Gradients Around Vessels

Gradient Echo versus Spin Echo Sensitivity to Vessel Size

Factors Affecting Spatial Resolution

How Can we Overcome Limits to Spatial Resolution?

Factors Affecting Temporal Resolution

How Can we Overcome Limits to Temporal Resolution?

So What Resolution Can be Achieved?

Conclusions

Web Address

Author: Peter Jezzard

Email: peterj@fmrib.ox.ac.uk

Home Page: http://www.fmrib.ox.ac.uk

Other information:
FMRIB Centre, University of Oxford, John Radcliffe Hospital, Headington, Oxford, OX3 9DU, ENGLAND