Kyle Pattinson, BM DPhil FRCA 
MRC Clinician Scientist Fellow
Consultant Anaesthetist
Nuffield Department of Anaesthetics, University of Oxford
John Radcliffe Hospital, Headington, Oxford OX3 9DU, UK

E-mail:

kyle.pattinson @ nda.ox.ac.uk

 

Publications

 Original Research

  1. Wise RG, Pattinson KT, Bulte DP, Rogers R, Tracey I, Matthews PM, Jezzard P. Measurement of relative cerebral blood volume using BOLD contrast and mild hypoxic hypoxia. Magnetic Resonance Imaging, 2010; 28: 1129-34. [download]

  2. Pattinson KTS, Governo RJ, MacIntosh BJ, Russell EC, Corfield DR, Tracey I, Wise RG . Opioids depress cortical centres responsible for the volitional control of respiration. Journal of Neuroscience, 2009; 29: 8177-8186 [download]

  3. Mitsis GD, Governo RJ, Rogers R, Pattinson KTS. The effect of remifentanil upon respiratory variability, evaluated with dynamic modeling. Journal of Applied Physiology, 2009; 106:1038-49 [download]

  4. Pattinson KTS, Mitsis GD, Harvey AK, Jbabdi S, Dirckx S, Mayhew SD, Rogers R, Tracey I, Wise RG. Determination of the human brainstem respiratory control network and its cortical connections in vivo using functional and structural imaging. NeuroImage, 2009; 44: 295-305 [download]

  5. Harvey AK, Pattinson KTS, Brooks J, Mayhew SD, Jenkinson M, Wise RG. Brainstem functional magnetic resonance imaging: disentangling signal from physiological noise. Journal of Magnetic Resonance Imaging, 2008; 28: 1337-44. [download]

  6. MacIntosh BJ, Pattinson KTS, Gallichan D, Ahmad I, Miller KL, Feinberg DA, Wise RG, Jezzard P. Measuring the effects of remifentanil on cerebral blood flow and arterial arrival time using 3D MRI with pulsed arterial spin labeling. Journal of Cerebral Blood Flow and Metabolism, 2008; 28: 1514-22. [abstract]

  7. Imray CHE, Pattinson KTS, Myers SD, Chan CW, Hoar H, Brearey S, Collins P, Wright AD and the Birmingham Medical Research Expeditionary Society. Intrapulmonary and intra-cardiac shunting with exercise at altitude. Journal of Wilderness and Environmental Medicine, 2008; 19: 199–204. [abstract]

  8. Myers SD, Biccard BM, Chan CW, Wright AD, Pattinson KTS. Delayed Acclimatization of the Ventilatory Threshold in Healthy Trekkers. Journal of Wilderness and Environmental Medicine, 2008; 19:124-8. [abstract]

  9. Wise RG, Pattinson KTS, Bulte DP, Chiarelli PA, Mayhew SD, Balanos GM, O'Connor D, Pragnell T, Robbins PA, Tracey I, Jezzard P. Dynamic forcing of end-tidal carbon dioxide and oxygen applied to functional magnetic resonance imaging. Journal of Cerebral Blood Flow and Metabolism, 2007; 27: 1521-32. [abstract] [pdf]

  10. Pattinson KTS, Rogers R, Mayhew SD, Tracey I, Wise RG. Pharmacological FMRI: measuring opioid effects upon the BOLD response to hypercapnia. Journal of Cerebral Blood Flow and Metabolism, 2007; 27: 414-423 [abstract] [pdf]

  11. Pattinson KTS, Bowes M, Wise RG, Parkes MJ, Morrell MJ. Evaluation of a non-invasive method of assessing opioid induced respiratory depression. Anaesthesia, 2005; 60:426-32.[abstract][pdf]

  12. Imray CHE, Myers SD, Pattinson KTS, Bradwell AR, Chan CW, Harris S, Collins P, Wright AD and the Birmingham Medical Research Expeditionary Society.  Effect of exercise on cerebral perfusion in humans at high altitude.  Journal of  Applied Physiology, 2005; 99:699 - 706    [abstract] [pdf]

  13. Chan CWM, Hoar H, Pattinson KTS, Bradwell AR, Wright AD, Imray CHE and the Birmingham Medical Research Expeditionary Society. The Effect of Sildenafil and Acclimatization on Cerebral Oxygenation at Altitude.  Clinical  Science (London), 2005; 109: 319-24 [html] [pdf]

  14. Imray CHE, Kennedy CH, Pattinson KTS, Brearey S, Wright A and the Birmingham Medical Research Expeditionary Society. Self-assessment of acute mountain sickness in adolescents: a pilot study. Journal of Wilderness and Environmental Medicine,2004; 15: 202-206 [abstract] [pdf]]

  15. Pattinson KTS, Myers S, Gardner-Thorpe C.  Problems with Capnography at High Altitude.  Anaesthesia, 2004; 59: 69-72[abstract][pdf]

 

Other Papers:

  1. Pattinson KTS Wise RG. Imaging the respiratory effects of opioids in the human brain. Advances in Experimental Medicine and Biology, 2010; [in press]. (book chapter)

  2. Pattinson KTS. Opioids and the Control of Respiration. British Journal of Anaesthesia, 2008; 100: 747-58. (review article) [download]

  3. Firth PG, Pattinson KTS. Anaesthesia and high altitude: a history. Anaesthesia, 2008; 63: 662-70 [abstract]

  4. Pattinson KTS, Wynne-Jones G Imray C.  Monitors of Cerebral Pressure, Perfusion and Metabolism.  Continuing Education in Anaesthesia, Critical Care and Pain, 2005; 5: 130-3. (educational article) [pdf]

  5. Davis PR, Pattinson KTS, Mason NP, Richards P, Hillebrandt D. High Altitude Illness. Journal of the Royal Army Medical Corps, 2005; 151: 243-9 [pdf]

  6. Pattinson KTS, Somogyi R, Fisher J, Bradwell AR.  Efficient rebreathing circuit for use at altitude.  Case report. Journal of Wilderness and Environmental Medicine, 2005; 16: 101-3 [abstract] [pdf]

  7. Pattinson KTS, Matthews S. Climbing the education mountain: designing the new Diploma in Mountain Medicine for the United Kingdom. Journal of Wilderness and Environmental Medicine, 2004; 15: 44-49 [pdf]

 

Letters: 

  1. Kalson NS, Stubbings AH, Collins HL, Pattinson KTS, Wright AD, and the Birmingham Medical Research Expeditionary. UK High altitude research: A report from the Birmingham Medical Research Expeditionary Society Altitude Research Conference, 4th December 2009 held at the Birmingham Medical Institute, UK Journal of Wilderness and Environmental Medicine, 2010; [in press]

  2. Pattinson KTS, Rogers R, Mayhew SD, MacIntosh BJ, Lee MC, Wise RG. Remifentanil-Induced Cerebral Blood Flow Effects in Normal Humans: Dose and ApoE Genotype. Anesthesia and Analgesia, 2008; 106: 347

  3. Russell EC, Pattinson KTS. Maternal satisfaction with computer integrated patient controlled epidural analgesia. Anaesthesia, 2006; 61: 811-2 [pdf]

  4. Imray CH, Pattinson KTS. Potential role for TCD-directed antiplatelet agents in symptomatic carotid artery dissection. Stroke, 2006; 37: 767 [pdf]

  5. Pattinson KTS, Imray C. Transcranial Doppler and carotid artery disease strokes – more than just risk stratification.  Stroke, 2005; 36:2340-1 [pdf]

  6. Pattinson KTS, Imray C, Wright AD. What does cerebral spectroscopy measure?  British Journal of Anaesthesia, 2005; 94: 863 [pdf]

  7. Pattinson KTS, Imray C. Another ‘double tails-up’ capnograph.  Anaesthesia, 2005; 60: 97-98 [pdf]

  8. Pattinson KTS, Sutherland AI, Smith TG, Dorrington KL, Wright AD. Acute Mountain Sickness, Vitamin C, Free Radicals and HIF-1α.  Journal of Wilderness and Environmental Medicine, 2005; 16: 172-5[pdf]

  9. Pattinson KTS, Imray C.  Adolescents at Altitude.  Journal of Wilderness and Environmental Medicine, 2005; 16: 60 [pdf]

  10. Imray C, Pattinson KTS. Surgery for carotid artery stenosis and ‘stroke prevention units’.  British Medical Journal, 2004; 329: 1344 [pdf]

  11. Pattinson KTS, Todd I, Thomas J, Wyse M. A two year review of laryngeal mask use by the Warwickshire ambulance service.   Emergency Medical Journal,2004; 21: 397-398 [pdf]

  12. Pattinson KTS, Imray CHE, Clutton-Brock TH. Validity of near-infrared cerebral spectroscopy. Anaesthesia, 2004; 59: 507-508 [pdf]

  13. Pattinson KTS.  Altitude Sickness in Youth Groups. Journal of Wilderness and Environmental Medicine,  2003; 14:153 [pdf]


 

Conference Paper:

  1. Mitsis GD, Harvey AK, Dirckx S, Mayhew SD, Rogers R, Tracey I, Wise RG, Pattinson KTS.   Modeling of dynamic CO2 reactivity in the human brainstem using BOLD fMRI.  8th IEEE International Conference on BioInformatics and BioEngineering, BIBE 2008. Article number 4696667


 

 Published abstracts

  1. Wise R.G, Dirckx S, Russell E, Johnson A, K. Pattinson, and Iannetti G. Opioids selectively reduce laser-evoked FMRI responses Proc Human Brain Mapping 16, 2010, 1425. [html]

  2. Wise R.G, A. Jolly, C. J. Evans, K. Murphy, F. Zelaya, D. Lythgoe, K. Pattinson, and J. E. Hall. Opioids induce regionally specific increases and decreases in cerebral blood flow Proc Human Brain Mapping 16, 2010, 875. [html]

  3. Wise R.G, A. Jolly, C. J. Evans, K. Murphy, F. Zelaya, D. Lythgoe, K. Pattinson, and J. E. Hall. Opioid-induced changes in cerebral blood flow in the human brain during controlled breathing Proc ISMRM 18, 2010 [in press].

  4. Croxson PL, Pattinson KTS, Baxter MG. Mapping the topography of fibres contributing to the fornix in the human brain using diffusion tractography Proc Human Brain Mapping 15, (2009) 536. [html]

  5. Pattinson KTS, Opioids, Breathing, and Brain Imaging. Proceedings of the Latvian Academy of Sciences, 2008; 62 (supplement).

  6. Pattinson KTS Functional and structural imaging of opioid effects on respiratory control Journal of Sleep Research 2008;17 (Suppl 1): 56

  7. Pattinson KTS, Governo RJ, Russell EC, MacIntosh BJ, Ahmad I, Mayhew SD, Corfield DR, Tracey I, and Wise RG. Opioids modulate the brain activity associated with breath-holding, an FMRI study Proc Human Brain Mapping 14 680T. [html]

  8. Pattinson KTS, Governo RJ, Russell EC, MacIntosh BJ, Ahmad I, Mayhew SD, Corfield DR, Tracey I, and Wise RG. The effect of remifentanil upon the conscious control of breathing. Proc ISMRM 16, 2008; 2512.

  9. MacIntosh BJ, Pattinson KTS, Gallichan D, Ahmad I, Miller KL, Feinberg D, Jezzard P.Using 3D GRASE-ASL to measure Hypercapnic changes in Cerebral Blood Flow and Arterial Arrival Time Proc ISMRM 16, 2008; 2348.

  10. Brooks J, Harvey A Pattinson KTS, Jenkinson M, Wise RG. Improved physiological noise modelling for brainstem functional imaging Proc ISMRM 16, 2008; 2452.

  11. Mayhew SD, MacIntosh BJ, Dirckx SG, Pattinson KTS, Wise RG. Is the habituation of the visual evoked EEG response reflected in the simultaneously acquired BOLD and ASL fMRI signals? Proc ISMRM 16, 2008; 2424.

  12. Pattinson KTS, Mitsis GD, Harvey AK, Jbabdi S, Dirckx S, Mayhew SD, Rogers R, Tracey I, Wise RG. Imaging structure and function of respiratory control in the human brainstem British Journal of Anaesthesia 2008; 100: 582P-583P [pdf]

  13. Pattinson KTS, Governo R, Russell EC, Rogers R, Tracey I, Wise RG, Mitsis G. Modelling the effect of remifentanil upon respiratory variability Anaesthesia, 2008; 63: 908 [pdf]

  14. Mitsis GD, Pattinson KTS, Harvey AK, Dirckx S, Mayhew SD, Hoar DH, Rogers R, Tracey I, Wise RG. Modelling of dynamic CO2 reactivity in the human brainstem using BOLD FMRI. Proc Human Brain Mapping 13, (2007) 327. NeuroImage 2007; 36 sup 1: 327 [html]

  15. Mayhew SD, Iannetti GD, Rogers R, Pattinson KTS, Wise RG. Wavelet time-frequency analysis of laser-evoked potential (LEP) power modulated by opioid induced analgesia. Proc Human Brain Mapping 13, (2007) 320. NeuroImage 2007; 36 sup 1: 320 [html]

  16. Dirckx SG, Mayhew SD, Pattinson KTS, Iannetti GD, Wise RG. Modulation of spontaneous and stimulus-evoked EEG activity during hypercapnia. Proc Human Brain Mapping 13, (2007) 374. NeuroImage 2007; 36 sup 1: 374 [html]

  17. Pattinson KTS, Mitsis GD, Harvey AK, Dirckx S, Mayhew SD, Hoar DH, Rogers R, Tracey I, Wise RG. Mapping BOLD sensitivity to CO2 in the human brainstem. Proc ISMRM 15,(2007); 2082

    [pdf]

  18. Pattinson KTS, Mitsis GD, Harvey AK, Dirckx S, Mayhew SD, Hoar DH, Rogers R, Tracey I, Wise RG. Natural fluctuations in CO2 induce low frequency variation in the BOLD signal, in the human brainstem. Proc ISMRM 15,(2007); 614

    [pdf]

  19. Wise RG, Pattinson KTS, Bulte DP, Chiarelli PA, Mayhew SD, Balanos GM, O'Connor D, Pragnell T, Robbins PA, Tracey I, Jezzard P. Dynamic forcing of end-tidal carbon dioxide and oxygen applied to functional magnetic resonance imaging. Proc ISMRM 15,(2007); 114

  20. Wise RG, Iannetti GD, Mayhew SD, Rogers R, Pattinson KTS, Tracey I. Assessment of opioid-induced analgesia and hyperalgesia using laser-evoked potentials. Proc Human Brain Mapping 12, (2006); 429 [html]

  21. Pattinson KTS, Mayhew SD, Rogers R, Tracey I, Wise RG. Pharmacological FMRI: measuring opioid effects upon the BOLD response to hypercapnia. Proc ISMRM 14,(2006); 1159 [pdf]

  22. Mayhew SD, Rogers R, Dunckley P, Pattinson KTS, Tracey I, Wise RG. Does mild hypoxia modulate the stimulus-evoked BOLD response? Proc ISMRM 14 (2006); 2766[pdf]

  23. Chan C, Rhodes H, Chesterman K, Collins P, Pattinson KTS, Imray C, Wright A. Peripheral vascular response is delayed in acute acclimatization to hypobaric hypoxia. High Alt Med & Biol., 2006; 7: 324 [pdf]

  24. Chan C, Rhodes H, Chesterman K, Collins P, Pattinson KTS, Imray C, Wright A. Arterial compliance and vascular tone in acute mountain sickness. High Alt Med & Biol., 2006; 7: 324-5 [pdf]

  25. Pattinson KTS, Wright AD, Chan CW, Imray CHE. Exercise-induced right to left shunting in healthy humans at high altitude. High Alt Med & Biol., 2006; 7: 339-340 [pdf]

  26. Pattinson KTS, Imray CHE, Myers SD, Chan CW, Wright AD, Biccard BM. Effect of acclimatisation on the ventilatory threshold in humans at high altitude. A key to understanding substrate utilisation associated with acclimatisation at high altitude. High Alt Med & Biol., 2006; 7: 340 [pdf]   [poster]

  27. Wise RG, Bulte D, Chiarelli P, Tjandra T, Pattinson KTS, Rogers R, Tracey I, Matthews P, Jezzard P.  Towards the measurement of relative CBV using BOLD contrast and a mild hypoxic challenge.  Proc ISMRM 13 (2005); 1491[pdf]

  28. Chan CWM, Hoar H, Pattinson KTS, Bradwell AR, Wright AD, Imray CHE and BMRES The time course of the effect of sildenafil on the increase in cerebral oxygenation at altitude.  Adv Exp Med Biol, 2005; 588; 339

  29. Barry P, Pattinson KTS, Hillebrandt D.  Climbing the education mountain: Educational appraisal of the first two years experience of the UK diploma in mountain medicine.  Adv Exp Med Biol, 2005; 588; 312-313 [pdf]

  30. Wright AD, Collins P, Imray CHE, Pattinson KTS, Myers SD, Chan CWM, Bradwell AR, and BMRES.  Blood pressure changes during exercise at altitude High Alt  Med & Biol., 2004; 5: 509 [pdf]

  31. Imray CHE, Pattinson KTS, Myers SD, Wright AD, and the BMRES.  “Virtual altitude’:  A hypothesis which may explain why exercise exacerbates AMS.  High Alt Med & Biol., 2004; 5: 488 [pdf]

  32. Pattinson KTS, Mason NP, Richards PR, Davis P, Swazarski P, Hillebrandt DH. Advances in Mountain Medicine Education in the United Kingdom. High Alt Med & Biol., 2004; 5: 498 [pdf]

  33. Pattinson KTS, Beazley MF, Forster P, Hillenbrand P, Somogyi R, Preiss D, Prisman A, Vesely A, Goodman L. Treatment of HAPE and HACE with novel breathing system: case report. High Alt Med. & Biol., 2002; 3: 450 [pdf]

  34. Pattinson KTS, Myers S, Milles J, Imray C. Oxygen consumption whilst climbing mountains – is a slow plod strategy better than rush and rest? High Alt Med. & Biol., 2002;  3: 437 [pdf]

  35. Pattinson KTS, Myers S, Gardner-Thorpe C. Capnography at high altitude. High Alt Med. & Biol., 2002;  3: 444 [pdf]

  36. Chan C, Collins P, Wright A, Pattinson KTS, Forster P, Imray C. The effect of an oxygen bolus on cerebral oxygenation and blood flow at altitude. High Alt Med. & Biol., 2002;  3: 442 [pdf]

  37. Chan C, Collins P, Imray C, Pattinson KTS, Chesner I, Clarke T, Harvey T. Improved cerebral oxygenation during acute hyperventilation at altitude is not due to improved cerebral blood flow.  High Alt Med. & Biol., 2002, 3: 443 [pdf]

  38. Azami T, Preiss D,Goodman L, Somogyi R, Prisman E, Vesely A, Iscoe S, Pattinson KTS, Bradwell J. Hypocapnia contributes little to increasing SaO2 at altitude. High Alt Med. & Biol., 2002,  3: 445 [pdf]

  39. Vesely A, Somogyi R, Azami T, Preiss D, Prisman E, Goodman L, Iscoe S, Pattinson KTS, Bradwell J, Imray C, Fisher J. Field testing of a new high-altitude O2 delivery system in the Bolivian Andes.  High Alt Med. & Biol., 2002, 3: 434 [pdf]





This page was updated on 5th July 2010