Kyle Pattinson, BM DPhil FRCA 
MRC Clinician Scientist Fellow
Consultant Anaesthetist
Nuffield Department of Anaesthetics, University of Oxford
John Radcliffe Hospital, Headington, Oxford OX3 9DU, UK

E-mail:

kyle.pattinson @ nda.ox.ac.uk

 

Research Interests

FMRI of Respiratory Control.

Disorders of respiratory control are implicated in a wide spectrum of disease including: chronic obstructive airways disease, asthma, neurodegenerative diseases, sleep apnoea and sudden infant death syndrome. In particular, chronic obstructive airways disease causes distressing shortness of breath, and is one of the major debilitating diseases in the world. Drugs used for pain relief, such as morphine, have potentially fatal side effects due to their effects upon respiratory centres in the brain. My research centres upon investigating mechanisms of respiratory control, and the processes underlying breathlessness, using non-invasive magnetic resonance imaging techniques.


Imaging brain perfusion changes following aneurysmal subarachnoid haemorrhage


Vasospasm (or "delayed ischaemic neurological deficit") is a major cause of morbidity and mortality following subarachnoid haemorrhage. Successful targeted treatment requires an accurate, non-invasive, and reproducible measure of cerebral perfusion. Current techniques are limited in their clinical application as they only image larger arteries and require the use of contrast agents and/or ionising radiation. We are trialing novel magnetic resonance imaging techniques that do not require exogenous contrast agents that demonstrate quantitative measures of cerebral perfusion at the tissue level. This would potentially facilitate the early and targeted use of vasospasm therapies and so reduce long-term morbidity and mortality.


Publications




Grants

Oxford Respiratory FMRI Meeting, 10th October 2007





Research group

Mari Herigstad - Postdoctoral Research Associate

Michael Kelly - Postdoctoral Research Associate

Anja Hayen - DPhil Student

Eleanor Mishra - Specialist Registrar & Research Fellow, Respiratory Medicine

Matt Rowland - Specialist Registrar & Research Fellow, Anaesthetics



Collaborations

Professor Richard Wise, Director & MRC Career Development Fellow, CUBRIC, School of Psychology, University of Cardiff


Dr Robert B Banzett, Associate Professor, Harvard Medical School, Division of Pulmonary & Critical Care Medicine, Beth Israel Deaconess Medical Center




Links

Nuffield Department of Anaesthetics

FMRIB

BMRES - The Birmingham Medical Research Expeditionary Society





Altitude sickness information

UIAA Medical pages - including specific advice on climbing Mt Kilimanjaro

Travel at high altitude - free downloadable book in many languages


Last updated: 21st July 2010